• Nicole Flanigan

Terpene Isolates 101: b-Caryophyllene

Updated: Feb 21

If you're just getting started with terpenes, odds are you're wondering how each isolate can be used. Terpene isolates can be used in hemp, CBD, and cannabis products as well as concentrates, vapes, and even in foods, beverages, and aromatherapy infusions. This week, we're diving deeper into the peppery-spice terpene isolate that acts similarly to cannabinoids, b-Caryophyllene. This isolate is best known for its antioxidant and pain-relieving properties, along with a variety of other body modulating effects.

Beta-Caryophyllene Terpene Isolate

Beta-Caryophyllene, sometimes simply referred to as Caryophyllene, is a large, unique terpene isolate that tends to act more like a cannabinoid than your average terpene. Unlike Linalool or Myrcene terpenes, Caryophyllene terpenes are much larger molecules and affect our bodies differently. Caryophyllene's molecular structure also contains a cyclobutane ring, which is a rare occurrence in nature and not found in other terpenes. Aside from spicy cannabis strains like Sour Diesel and Chemdawg, Caryophyllene is usually found in herbs and spices like black pepper, oregano, and hops. Caryophyllene is directly responsible for the pungent spicy associated with cloves, anise, and cinnamon.


Cannabis strains high in Caryophyllene are normally described as funky. Caryophyllene terpenes smell skunky and musky or carry notes of diesel and fuel. This nose-tingling bite is predominant in many cookies cuts, including Girl Scout Cookies, Platinum GSC, Gelato, and Do-si-dos. However, you can also find high concentrations of Caryophyllene terpenes in strains like Bubba Kush, Candyland, Death Star, Gorilla Glue #4 (AKA Original Glue), and Master Kush.

Photo by Matthew Brodeur on Unsplash

Unlike most terpenes, Caryophyllene doesn't cause any unique mood-altering feelings like calm or energy. However, it can affect conditions like clinical depression and anxiety in the way it acts similarly to a cannabinoid and binds to receptors in our endocannabinoid systems. Unlike any other terpene, b-caryophyllene is capable of directly binding to and activating our CB2 endocannabinoid receptors, which send messages to body systems and organs. This unique ability allows Caryophyllene to offer several medical benefits, like reducing inflammation and acting as an antioxidant.


The endocannabinoid system found within the human body is made up of hundreds of receptors that work to send messages to the brain and nervous system as well as body cells and organs. There are two main types, including CB1 and CB2 receptors. CB1 receptors are responsible for modulating and sending messages within the brain and nervous system, while CB2 receptors are found mainly in peripheral organs, like the digestive system or muscular system.


Most cannabinoids like THC stick to the CB1 receptors and cause us to feel high and euphoric. However, some cannabinoids like CBD and terpenes like Caryophyllene bind to the CB2 receptors, which affect sensations and body processes and can reduce inflammation and pain relief by stimulating these receptors to produce natural chemicals that reduce inflammation.


Caryophyllene makes a great addition to any CBD products since these two compounds work similarly. Not only does adding additional terpenes improve odors and flavors of CBD isolates, but it can also enhance the effectiveness of CBD products. Caryophyllene and CBD work together in a phenomenon known as the entourage effect. The entourage effect shows how terpenes and cannabinoids work together and complement each other's effectiveness. Caryophyllene and CBD work together to better absorb into the blood-brain barrier while binding to CB2 receptors that trigger analgesic, pain-relieving responses, ultimately doubling-down on the pain-relieving properties of both CBD and b-Caryophyllene.


Benefits of b-Caryophyllene Terpene Isolate

Aside from the entourage effect and boosting the effectiveness of cannabinoids, b-Caryophyllene itself acts similarly to a cannabinoid in the way it binds to CB2 receptors. Studies have shown that this unique ability highlights a ton of health benefits. We know it's an effective pain reliever thanks to a 2014 study on rodents, but we've also learned that b-Caryophyllene can reduce the way our bodies react to and process alcohol, indicating that it may be a good treatment option for addiction in the future.


Caryophyllene is also a potent antioxidant and anti-inflammatory terpene. Because of the way it binds to our CB2 receptors found within the digestive system, studies also indicate that it may someday be used as a treatment for inflammatory bowel diseases such as Chron's disease and irritable bowel syndrome. Many other studies have highlighted its effectiveness in killing certain cancer cells in the same way cannabinoids as CBD do.

Most interestingly, studies have shown that Caryophyllene can treat chronic anxiety and depression in the way it triggers responses within our endocannabinoid systems. In fact, Caryophyllene may improve your lifespan by lowering the way your body physically reacts to stress.


TLDR; b-Caryophyllene Benefits

  • Can improve metabolism

  • Can inhibit the growth of cancer cells and induces apoptosis

  • Can help reduce muscle spasms and muscle pain.

  • Can protect against neurodegeneration and reduce neuroinflammation (by reducing blood-brain barrier related inflammation)

  • Can reduce pain (by increasing natural endorphins)

  • Can help to increase glutathione levels which can increase protection against glutamate-induced oxidative stress.

  • Can decrease brain damage after stroke.

  • Can enhance the effects of some anti-cancer drugs, such as paclitaxel and

  • doxorubicin.

  • Can decrease the time it takes to get to sleep and increase sleep time.

  • Can help improve blood flow to the brain and can help with Vascular Dementia (VD).

  • Can help reduce high levels of cholesterol (hypercholesterolemia) stress to the heart and It may also suppress the development of atherosclerosis.

  • Can help inhibit dopamine loss and oxidative stress in the brain

  • May help with Inflammatory Bowel Diseases

  • May inhibit dental plaque buildup and may also help to prevent gingivitis

  • May reduce depressive and obsessive-compulsive symptoms.

  • May help relieve chronic pain and neuropathy.

  • May help with alcohol dependence.

  • May potentiate the analgesic action of morphine.

Common uses for b-Caryophyllene Isolate

Caryophyllene terpenes can be safely added to all sorts of products to encourage natural body responses. It can safely be eaten, drank, infused, and inhaled with a little bit of mixing. It can also be used to improve cannabis products like vapes and concentrates that may have lost cannabinoid potency or terpene content during extraction.


Add b-Caryophyllene terpenes to foods and beverages to enjoy the anti-anxiety, pain-relieving, and system modulating properties within the whole body. A few drops in your favorite spicy dishes taste peppery and zesty and can help your body start working more efficiently. Adding Caryophyllene to your food or beverages can help reduce inflammation and the symptoms of inflammatory bowel diseases as well as stomach and intestinal pain.


Add b-Caryophyllene terpenes to essential oil diffusers and aromatherapy infusions to introduce the benefits of this terpene into the respiratory system without having to smoke it. As a bonus, it smells pungent and spicy!


Add b-Caryophyllene terpenes to cannabis concentrates made from strains with higher Caryophyllene content, such as Cookies and Cream or The White, to improve quality, potency, flavor, and effects. You can even add Caryophyllene to CBD isolates to help make your CBD more active within the body.

Just keep in mind that not all terpenes are created equal. Different terpenes will always have different effects, but they're not all made the same. We know you have a choice when it comes to terpene providers, but no other choice comes close to our level of quality. At Peak Supply Co, our b-Caryophyllene terpene isolates are extracted from all-natural food-grade fruit, flower, and nut oils in our state-of-the-art facility. With our proprietary extraction and refinement method, we remove plant materials and any leftover impurities, leaving behind the purest terpene isolates on the market. Best of all, we even offer sample packs so you can try them all!

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NOTICE: 100% THC & CBD FREE products. Our Products DO NOT CONTAIN Cannabis or Hemp.
All Terpenes are sold as natural flavor & aroma enhancers and are intended for use in many types of products from food to perfume.
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