• Nicole Flanigan

Terpenes 101: Caryophyllene Oxide

If you're just getting started with terpenes, odds are you're wondering how each isolate can be used. Terpene isolates can be used in hemp, CBD, and cannabis products as well as concentrates, vapes, foods, beverages, and aromatherapy infusions. In fact, adding terpenes to health and beauty products, cosmetics, vaporizer cartridges, and e-juice, foods and beverages, and aromatherapy infusions is a great way to add an extra boost of body-nourishing benefits to your products and make THC/CBD products more effective. This week, we're diving deeper into the funky, spicy, and wood-scented isolate known as Caryophyllene Oxide.

Terpenes 101: Caryophyllene Oxide (found in guava fruit)

Caryophyllene Oxide Terpenes

Caryophyllene Oxide is a sesquiterpene that occurs when b-Caryophyllene becomes oxidized. this typically happens during the curing process with cannabis, though it also appears in many dried spices like basil, black pepper, and oregano and is responsible for a spicy, warm, and funky aroma similar to cloves and cinnamon. It's considered non-toxic and has been studied a lot recently thanks to its anticoagulant, anticancer, and anti-inflammatory effects


While Caryophyllene Oxide has been used in cosmetics, medicines, and food preservatives, it has also been used for training drug-sniffing dogs by law enforcement. Most studies have been conducted on oils containing Caryophyllene Oxide terpenes in addition to other terpenes since it's difficult to narrow down specific effects of individual isolates. Terpenes are known to work in synergy to boost the effects of one another in a phenomenon known as the entourage effect, which is part of the reason they're always studied together.


Below, we're covering everything you need to know about the uses, effects, and natural sources of Caryophyllene Oxide terpenes. Keep in mind that the scientific community is still studying Caryophyllene Oxide terpenes, so we don't have every effect of this isolate narrowed down yet. That said, there may still be unknown side effects of Caryophyllene Oxide terpenes. Always talk to your doctor before beginning a new dietary supplement, even one with naturally occurring terpenes like Caryophyllene Oxide.


Benefits of Caryophyllene Oxide Terpenes

There are several benefits associated with Caryophyllene Oxide terpenes. For one thing, it acts similarly to b-Caryophyllene and other cannabinoids by binding to the CB2 receptors in our endocannabinoid systems. In the case of cannabis, Caryophyllene Oxide is exceptionally synergistic with cannabinoids. With CBC or CBG it acts as an antifungal. With THC it acts as an anticoagulant, and it's insecticidal when found with CBG-a and THC-a.

Terpenes 101: Caryophyllene Oxide (found in dried herbs and spices)

It has several effects when taken both internally and applied externally. On the external side, Caryophyllene Oxide is used topically as an antifungal agent. It's often compared to sulconazole and ciclopirox and used to treat toenail fungus and other fungi of the skin or nails. Like most terpenes, it's also a potent antibacterial agent and is used in many commercial cleaners. It has insecticidal properties when found in the cannabis plant, too.


When taken internally, Caryophyllene Oxide's ability to bind to our CB2 receptors makes it possible for it to provide intense relief from pain as well as reduce inflammation. It also acts as a potential anticoagulant by displaying anti-platelet aggregation activity. Similar to b-Caryophyllene, Caryophyllene Oxide potentiates anti-cancer drug efficacy. It also shows anticancer activities against leukemia, prostate cancer, and multiple myeloma cell lines.


Last but not least, like all terpenes, Caryophyllene Oxide is lightly psychoactive, offering a relaxing aroma that may help against anxiety. All in all, it's a powerful terpene boasting a variety of health and therapeutic applications. Further study on this powerful terpene is needed to accurately assess its medicinal and wellness value, but science is already taking a closer look into this isolate. We're excited to see how useful it will be in due time.


Natural Sources of Caryophyllene Oxide Terpenes

Caryophyllene Oxide can be found in many plants alongside b-Caryophyllene terpenes. It appears in high concentrations in plants like eucalyptus, lemon balm, dried oregano, guava, black pepper, and clove. However, it also appears in many cured cannabis strains, including ACDC, Grape Inferno, Purple Punch, Blueberry Seagal, and Purple Wookie.

Terpenes 101: Caryophyllene Oxide — natural sources

TLDR; Caryophyllene Oxide Terpenes

  • Anti-inflammatory

  • Antibacterial

  • Antifungal

  • Anticoagulant

  • Anticancer

  • Insecticidal

  • Pain reliever

  • Reduces anxiety

  • Relaxing aroma

Common Uses of Caryophyllene Oxide Terpenes

Whether through your favorite fruits and spices or through an aromatherapy diffuser, Caryophyllene Oxide isolate smells and tastes great and does some pretty cool stuff both externally and within your body.


Caryophyllene Oxide terpenes can be safely added to all sorts of products to reduce inflammation, reduce anxiety, and kill cancer cells. It can safely be eaten, drank, infused, and inhaled with a little bit of mixing. It can also be used to improve cannabis products like vapes and concentrates that may have lost cannabinoid potency or terpene content during extraction.

Terpenes 101: Caryophyllene Oxide (found in peppercorns)

Add Caryophyllene Oxide terpenes to foods and beverages to enjoy the anti-inflammatory, antibacterial, and pain-relieving properties within the whole body. A dash of water-soluble Caryophyllene Oxide terpenes in your favorite foods or beverages add a spicy and funky flavor that can help to make you feel more relaxed and reduce stress. Add Caryophyllene Oxide terpenes to essential oil diffusers and aromatherapy infusions to kill airborne bacteria and microbes to help you breathe easier. The earthy, woody aroma is also great for promoting a relaxing, stress-free atmosphere to your daily routine or a great way to unwind at night. Add Caryophyllene Oxide terpenes to cannabis concentrates and hemp oils made from strains with higher earthy terpene content, such as b-Caryophyllene and Pinene since Caryophyllene Oxide is often found alongside these terpenes and offers similar flavors and effects. Caryophyllene Oxide terpenes can make them smell and taste better and boost the potency of THC/CBD or other cannabinoid effects in a documented phenomenon known as the Entourage Effect. Just keep in mind that not all terpenes are created equally. Different terpenes will always have different effects, but they're not all made the same. We know you have a choice when it comes to terpene providers, but no other choice comes close to our level of quality. At Peak Supply Co, our Caryophyllene Oxide terpene isolates are extracted from all-natural food-grade fruit, flower, and nut oils in our state-of-the-art facility. With our proprietary extraction and refinement method, we remove plant materials and any leftover impurities, leaving behind the purest terpene isolates on the market. Best of all, we even offer sample packs so you can try them all.

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